Juariah, siti and Juliantri, Erwina and Hanggara, Dika and Surya, Alfin and Endrini, Susi (2024) Chemical Profiling, Antifungal and Anti-inflammatory Evaluations of Ethanol Extract of Zingiber officinale var. rubrumand Curcuma caesiaMixture from Riau, Sumatera Island, Indonesia. Tropical Journal of Natural Product Research, 8 (1). pp. 5794-5800. ISSN 2616-0692

	Text 21. TJNPR+2023-M519-Galley+Proof-CF.pdf Download (521kB)
	Text 21. Hasil cek turnitin_TJNPR_syarat khusus (14%) (1).pdf Download (3MB)

Abstract

Invasive fungal infections can cause inflammation and stimulate immune response. Antifungals like plants possessing inherent anti-inflammatory activity, which can lead to rapid symptomatic relief while providing a mycologic cure is imperative. Plants with evidence of antifungal and anti-inflammatory activities are red ginger (Zingiber officinalevar. rubrum) and black turmeric (Curcuma caesia). The study aimed to investigate the chemical profile, the antifungal and anti-inflammatory activities ofthe ethanol extract of red ginger and black turmeric mixture in vitro. Chemical profiling was done using Liquid Chromatography-Mass Spectrophotometry(LC-MS). Antifungal activity was tested using the Kirby Bauer disc diffusion method by measuring the diameter of the inhibition zone. Anti-inflammatory activity was tested by measuring the toxicity and inhibition of nitric oxide (NO) production in macrophage-like RAW 264.7 cells. From the results of the LC-MS analysis, 22 compounds were identified from the ethanol extract of red ginger and black turmeric mixture. The mixture extract exhibited potent antifungal activity; with the 80% concentration being the most effective with an inhibition zone diameter of 11.6 mm. The extract exhibited a dose-dependent anti-inflammatory activity. The 7.5 μg/mL and 15 μg/mL of the mixture extract significantly reduced nitric oxide production in RAW 264.7 cellsby 0.62 and 19.854%, respectively. The mixture extract at 1000 μg/mL gave the highest proliferation inhibition of RAW 264.7 cells. On the basis of the results of the study, the extract of red ginger and black turmeric mixture has the potential to be used as an alternative antifungal and anti-inflammatory agent

Actions (login required)

View Item